Whether youre a student, an educator, or a lifelong learner, can put you on the path to systematic vocabulary improvement. The act or process of administering, especially the management of a government or large institution. Sublingual article about sublingual by the free dictionary. Buprenorphine is a synthetic thebaine derivative that has both analgesic and opioid antagonist properties. Enhanced bioavailability of triazolam following sublingual. Some medicines can be given sublingual, which means under the tongue. Sublingual tablets and the benefits of the sublingual route of. Sublingual administration involves placing a tablet under. Nitroglycerin sublingual tablets are indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease. Sublingual tablet definition of sublingual tablet by. A sublingual part, such as a gland, artery, or duct.
Sublingual literally meaning is under the tongue, administrating substance via mouth in such a way. In healthy volunteers, sublingual administration is associated with a higher c max, a higher bioavailability and a more accentuated initial natriuretic response than oral furosemide. Bioadhesive sublingual tablet the new sublingual tablet concept presented is based on interactive mixtures consisting of a watersoluble carrier covered with. Sublingual and buccal drug delivery flashcards quizlet. The sublingual route may also be used for vaccines against various infectious diseases. The sublingual route bypasses the firstpass metabolism and hence facilitates rapid absorption of the drug into the systemic circulation. Pdf the sublingual route is one of the early modes of administration for systemic drug delivery. Information and translations of administration, sublingual in the most comprehensive dictionary definitions resource on the web. Drugs for sublingual administration medically, sublingual drug administration is applied in the field of cardiovascular drugs, steroids, some barbiturates and enzymes. Definition of sublingual administration in the dictionary.
The performance of executive duties in an institution or business. Sublingual definition of sublingual by the free dictionary. Soluble tablets for either oral or sublingual administration. Nov 20, 2015 determining equivalence dose for oral versus sublingual administration of tacrolimus in hepatic receptors fkosl the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. What you should know about medicinessublingual wikibooks. Even swallowing saliva is to be avoided, to prevent ingestion through the. Mar 28, 2019 how to administer sublingual medication. Thus, this route of administration can offer attractive therapeutic advantages. The various routes of administrations are classified into following categories.
The administration of drugs by transdermal or transmucosal routes offers the advantage of being relatively painless. The sublingual route bypasses the firstpass metabolism and hence facilitates. Lorazepam sublingual side effects, medical uses, and drug. Sublingual literally meaning is under the tongue, administrating substance. Information and translations of sublingual administration in the most comprehensive dictionary definitions resource on the web. It has been a developing field in the administration of many vitamins and minerals which are found to be readily and thoroughly absorbed.
Sublingual administration of drug refers to the placement of drug under the tongue rehfeld et al. Definition sublingual abbreviated sl, from the latin for under the tongue, refers to the pharmacological route of administration by which. Mar 28, 2019 sublingual nitroglycerin is used in patients with coronary artery disease to relieve chest pain. The sublingual mucosa is the membrane of the ventral surface of the tongue.
Considerations in developing sublingual tabletsan overview. This method of sublingual dosing has been tried when a patients dr. Pdf drug delivery via the oral mucous membrane is considered to be a promising. Lorazepam sublingual side effects, medical uses, and. The rate and extent of the absorption of triazolam following sublingual and oral administration were evaluated in this study. Sublingual definition is situated or administered under the tongue. World allergy organization position paper 20 update. It involves placing the drug beneath the tongue, to be absorbed and dissolved into the bloodstream through the mucous membranes. The medications dissolve rapidly and are absorbed through the mucous membranes of the mouth, where they enter into the. Sublingual drug administration allows the drug to be directly absorbed into the systemic circulation, hence avoiding a rapid decrease in its bioavailability that can be caused by first pass metabolism.
Determining equivalence dose for oral versus sublingual. Sublingual definition, situated under the tongue, or on the underside of the tongue. The reason for this method of administration is that some medications can enter the bloodstream better or faster this way. Administration definition of administration by the free. The tablets depend on digestive function for the most part, which is one reason theyre not as effective.
Administration centage of opioid absorption of analgesics ocbecause the sublingual cavity is rich in blood curring in the oral cavity under controlled ph and lymphatic vessels, agents that cross the mu conditions. Systemic route a enteral route b parenteral route 1. Determining equivalence dose for oral versus sublingual administration of tacrolimus in hepatic receptors fkosl the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Efficacy of slit in children with detailed analysis of all the studies. Meaning of sublingual administration as a legal term. Sep 15, 2007 in healthy volunteers, sublingual administration is associated with a higher c max, a higher bioavailability and a more accentuated initial natriuretic response than oral furosemide. Sublingual and buccal medication administration are two different ways of giving medication by mouth. The small business administration is responsible for administration of some disasterrelief loans. The sublingual administration of opioid analgesics has been a mainstay in the pain management of homebound dying hospice patients who are no longer able to swallow. In government, the practical management and direction of some department or agency in the executive branch. World allergy organization position paper 20 update, according to the evidencebased. Phar 7633 chapter 7 routes of drug administration buccal and sublingual sl some drugs are taken as smaller tablets which are held in the mouth or under the tongue. Thus, preclinical studies have found that sublingual vaccines can be highly immunogenic and may protect against influenza virus 3 4 and heliobacter pylori, 5 but sublingual administration may also be used for vaccines against other infectious diseases. For example, a sublingual medication is a type of lozenge that is dissolved under the tongue.
These medications are transferred to the bloodstream from the. Pdf sublingual literally meaning is under the tongue, refers to a. Sublingual abbreviated sl, from the latin for under the tongue, refers to the pharmacological route of administration by which substances diffuse into the blood through tissues under the tongue which is predominantly a mucous gland primarily produces a thick mucinous fluid and lubricates the oral cavity which allows for swallowing, initiating digestion, buffering ph, and dental hygiene. Definition of administration, sublingual in the dictionary. Sublingual literally meaning is under the tongue, administrating substance via mouth in. Examples of the clinical use of sublingual drug administration include. Buccal delivery is the administration of a drug via the lining of the cheek. Pdf drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. The sublingual strip allows producers to more effectively control dosage quantities and significantly increases the effect of the cannabis, allowing it to be used for a range of purposes including pain management, concentration, as an antidepressant, and to support better sleep. Sublingual administration an overview sciencedirect topics. Sublingual definition of sublingual by merriamwebster. Pdf sublingual drug delivery system ankit patel academia.
Learn the differences, pros, cons, and considerations for each. Box80, patel nagar, dehradun 248001, uttarakhand, india abstract. Sublingual and buccal medications are administered by placing them in the mouth, either under the tongue sublingual or between the gum and the cheek buccal. Nitroglycerin sublingual tablet dosage and administration. These drugs are in the form of tablets that dissolve, sprays, or films. Sublingual abbreviated sl, from the latin for under the tongue, refers to the. About sublingual and buccal medication administration. Sublingual definition and meaning collins english dictionary.
What is always a problem for sublingual or buccal administration. Phar 7633 chapter 7 routes of drug administration boomer. Sublingual administration financial definition of sublingual. Definition of sublingual administration in the legal dictionary by free online english dictionary and encyclopedia. Rational use of sublingual opioids in palliative medicine. The benefit of sublingual vitamin b12 is that you dont need to rely on digestion.
About sublingual and buccal medication administration healthline. Sublingual and buccal medication administration definition. Definition of slit patient selection reporting the criteria for eligibility to sublingual. Descriptions of the study populations, study designs, and maximum. What is sublingual administration carefirst specialty. This route avoids firstpass metabolism and affords quick drug entry into the systemic circulation. It is also a potentially useful route of administration in other situations in which the oral route is not available and other routes are impractical or inappropriate. The absorption of morphine sulcosa of the mouth enter the systemic circula fate 18% was lower than that of buprenor. Read more about the prescription drug lorazepam sublingual. The new sublingual tablet concept presented is based on. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Sublingual route for systemic drug delivery amit kumar bind, g.
Sublingual and buccal medication administration are ways to take certain oral drugs. Sublingual administration may offer advantages over oral administration of furosemide in certain clinical situations. Sublingual medications are orally disintegrating or dissolving medications that are administered by being placed under the tongue. Sublingual injections rectal transdermal local routes it is the simplest mode of administration of a drug at the site where the desired action is required. What are some advantages of sublingualbuccal delivery. Pdf sublingual route for systemic drug delivery researchgate. Sublingual administration is a way of giving medication through the mouth. Here are a few guidelines on how to administer sublingual nitroglycerin. Purpose to ensure a consistent standardized practice for administering medications sublingually.
Administer one tablet under the tongue or in the buccal pouch at. Start studying sublingual and buccal drug delivery. A route of administration in pharmacy is the path by which a drug is taken into the body. Situated beneath or on the underside of the tongue.
Sublingual nitroglycerin is one of several forms of nitroglycerin, which also comes in a spray and a patch, and is one of the easiest to administer at the onset of chest pain. Buccal tablets are often harder tablets 4 hour disintegration time, designed to dissolve slowly. The sublingual route is one of the early modes of administration for systemic drug delivery. Adverse events commonly observed with the sublingual administration of buprenorphinenaloxone sublingual tablets during clinical trials and postmarketing experience are headache, nausea, vomiting, hyperhidrosis, constipation, signs and symptoms of withdrawal, insomnia, pain and peripheral edema. Buccal means relating to the cheeks or the mouth cavity. The sublingual route of administration can be used for drugs which undergo. Sublingual administration of the drug means placement of the drug. Sublingual administration definition of sublingual.
Sublingual, meaning literally under the tongue refers to a method. Approximately of an oral dose has the same effects when taken sublingually. Sublingual administration involves placing a tablet under the tongue and allowing it to dissolve. Oct 10, 2015 the tablets depend on digestive function for the most part, which is one reason theyre not as effective. Enhanced bioavailability of triazolam following sublingual versus oral administration. Buccal definition and meaning collins english dictionary. Consumer information about the medication lorazepam sublingual, includes side effects, drug interactions, recommended dosages, and storage information. Report problems to the food and drug administration. Sublingual administration legal definition of sublingual. Following sublingual administration, the patient is advised to abstain from swallowing the tablet and avoid eating, drinking, or chewing to facilitate drug absorption through the oral mucosa. Sublingual administration of opioids is particularly beneficial in the patient with cancer. Overview and appraisal of the current concept and technologies for. Is epinephrine administration by sublingual tablet feasible for the firtsaid treatmentof anaphylaxis.
138 514 613 1224 624 543 405 1068 924 176 943 1574 196 866 1270 809 670 1008 1404 199 579 1086 924 388 976 1040 209 113 830